Delta-9-tetrahydrocannabinol Delta-9 THC is one of the most well-known and studied cannabinoids found in the cannabis plant. Its historical use and cultural significance span thousands of years and across various societies, reflecting its deep-rooted impact on human civilization. Historically, the use of cannabis dates back to ancient civilizations. Archaeological evidence suggests that the earliest use of cannabis as a psychoactive substance can be traced to China around 2700 BCE. Emperor Shen Nong, a legendary figure in Chinese medicine, is credited with documenting the therapeutic properties of cannabis. In his writings, he described its use for various ailments, including pain and gastrointestinal issues. The Chinese pharmacopoeia from this period also highlighted cannabis seeds and leaves for their nutritional and medicinal value.

In India, cannabis has been integral to religious and cultural practices for millennia. The Vedic texts, such as the Atharva Veda, written around 1500 BCE, refer to cannabis as one of the five sacred plants, praising its medicinal and spiritual benefits. Cannabis was used in various forms, including bhang—a traditional preparation of cannabis mixed with milk, spices, and other ingredients. This concoction was consumed during festivals like Holi and played a role in religious rituals and social gatherings, signifying its cultural and spiritual importance. Moving westward, delta 8 vs delta 9 ancient Greeks and Romans also recognized the value of cannabis. Greek physician Dioscorides, in his work De Materia Medica, described cannabis as having pain-relieving properties and used it in treating wounds and injuries. Similarly, Roman author Pliny the Elder noted its use in alleviating pain and inflammation. During these times, cannabis was not only valued for its medicinal properties but also for its versatility as a fiber used in making ropes and textiles.

In the Middle Ages, the use of cannabis continued in various cultures. Islamic scholars, such as Avicenna, wrote about the therapeutic effects of cannabis in their medical texts. The plant spread across the Islamic world, where it was used for both medicinal and recreational purposes. Cannabis use also made its way to Africa, where it was used in traditional medicine and spiritual practices. The colonial era saw the spread of cannabis to the Americas. Early European settlers brought the plant with them, and it quickly became embedded in the cultural and economic fabric of various societies. In the 19th and early 20th centuries, cannabis was widely used in Western medicine for its analgesic and sedative effects. Its popularity grew, with tinctures and extracts becoming common in pharmacies. However, the cultural and legal landscape began to shift in the early 20th century. The prohibitionist movement in the United States, exemplified by the Marihuana Tax Act of 1937, led to the criminalization of cannabis and stifled research into its benefits. Despite this, cannabis continued to be used in various subcultures and underground circles.